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KMID : 0545120160260101696
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Journal of Microbiology and Biotechnology
2016 Volume.26 No. 10 p.1696 ~ p.1700
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Inhibition of the Calcineurin Pathway by Two Flavonoids Isolated from Miliusa sinensis Finet & Gagnep.
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Lee Won-Jeong
Moon Jae-Sun
Kim Young-Tae
Bach Tran The
Hai Do Van
Kim Sung-Uk
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Abstract
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In order to discover plant-derived signaling pathway inhibitors with antifungal properties, a two-component screening system utilizing the calcineurin and Hog1 mitogen-activated protein kinase pathways responsible for the virulence networks of Cryptococcus neoformans was employed, owing to the counter-regulatory actions of these pathways. Of the 1,000 plant extracts tested, two bioactive compounds from Miliusa sinensis were found to act specifically on the calcineurin pathway of C. neoformans. These compounds, identified as pashanone and 5-hydroxy-6,7-dimethoxyflavanone, exhibited potent antifungal activities against various human pathogenic fungi with minimum inhibitory concentration values ranging from 4.0 to >128 μg/ml.
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KEYWORD
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Miliusa sinensis Finet & Gagnep., Cryptococcus neoformans, Virulence network, Two-component system, Calcineurin pathway
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